Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 14, Pages 1704-1707Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48390h
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Funding
- CRUK
- Marie-Curie for programme
- Biotechnology and Biological Sciences Research Council [BB/E013481/1] Funding Source: researchfish
- Cancer Research UK [12488] Funding Source: researchfish
- BBSRC [BB/E013481/1] Funding Source: UKRI
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We report here on the screening of a fragment library against a G-quadruplex element in the human c-MYC promoter. The ten fragment hits had significant concordance between a biophysical assay, in silico modelling and c-MYC expression inhibition, highlighting the feasibility of applying a fragment-based approach to the targeting of a quadruplex nucleic acid.
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