4.7 Article

A rolling circle amplification-based DNA machine for miRNA screening coupling catalytic hairpin assembly with DNAzyme formation

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 22, Pages 2935-2938

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49873e

Keywords

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Funding

  1. NSFC of China [41176079]
  2. 973'' National Basic Research Program of China [2010CB732403]
  3. NSF of Fujian Province [2011J06003]

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A novel DNA nanomachine based on the linear rolling circle amplification strategy was designed for sensitive screening of microRNA (miRNA) at an ultralow concentration coupling catalytic hairpin assembly (CHA) with DNAzyme formation.

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