Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 56, Pages 7427-7430Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00419a
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Funding
- National Basic Research Program of China (973 Program) [2012CB932502]
- National Science Foundation of China [U1332210, 21171156, 51390482, 51125012]
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Asplatin, a fusion of aspirin and cisplatin, exhibits significant cytotoxicity in tumor cells and almost fully overcomes the drug resistance of cisplatin resistant cells. Asplatin is highly accumulated in cancer cells and is activated upon the reduction by ascorbic acid.
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