Related references
Note: Only part of the references are listed.Enantioselective Synthesis of 4-Substituted Dihydrocoumarins through a Zinc Bis(hydroxyamide)-Catalyzed Conjugate Addition of Terminal Alkynes
Gonzalo Blay et al.
ADVANCED SYNTHESIS & CATALYSIS (2013)
Direct Conjugate Addition of Alkynes with α,β-Unsaturated Carbonyl Compounds Catalyzed by NCN-Pincer Ru Complexes
Jun-ichi Ito et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
Zinc Catalyzed and Mediated Asymmetric Propargylation of Trifluoromethyl Ketones with a Propargyl Boronate
Daniel R. Fandrick et al.
JOURNAL OF ORGANIC CHEMISTRY (2013)
Rhodium(I)-catalyzed 1,4-conjugate arylation toward β-fluoroalkylated electron-deficient alkenes: a new entry to a construction of a tertiary carbon center possessing a fluoroalkyl group
Atsunori Morigaki et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
Enantioselective Organocatalytic Michael Addition of Nitroalkanes and Other Nucleophiles to β-Trifluoromethylated Acrylamides
Lele Wen et al.
ACS CATALYSIS (2013)
Catalytic enantioselective addition of terminal 1,3-diynes to N-sulfonyl aldimines: access to chiral diynylated carbinamines
Tian-Lin Liu et al.
CHEMICAL COMMUNICATIONS (2012)
Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones
Yan Zheng et al.
CHEMICAL COMMUNICATIONS (2012)
Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines
Hiroyuki Kawai et al.
CHEMICAL COMMUNICATIONS (2012)
Practical synthesis of 4,4,4-trifluorocrotonaldehyde: a versatile precursor for the enantioselective formation of trifluoromethylated stereogenic centers via organocatalytic 1,4-additions
Kazutaka Shibatomi et al.
CHEMICAL COMMUNICATIONS (2012)
Enantioselective Zinc-Mediated Conjugate Addition of Terminal Alkynes to Enones
Gonzalo Blay et al.
CHEMISTRY-A EUROPEAN JOURNAL (2012)
Conjugate hydrotrifluoromethylation of α,β-unsaturated acyl-oxazolidinones: synthesis of chiral fluorinated amino acids
Holger Erdbrink et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Palladium-Catalyzed Conjugate Addition of Terminal Alkynes to Enones
Lara Villarino et al.
ORGANIC LETTERS (2012)
Zinc-mediated enantioselective addition of terminal 1,3-diynes to N-arylimines of trifluoropyruvates
Fa-Guang Zhang et al.
TETRAHEDRON (2012)
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist
Sean P. Brown et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
Asymmetric Autocatalysis Enables an Improved Synthesis of Efavirenz
Nicka Chinkov et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
C-1-Symmetric Rh/Phebox-Catalyzed Asymmetric Alkynylation of alpha-Ketoesters
Takashi Ohshima et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Catalytic Enantioselective Alkynylation of Trifluoromethyl Ketones: Pronounced Metal Fluoride Effects and Implications of Zinc-to-Titanium Transmetallation
Guang-Wu Zhang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Highly enantioselective zinc/BINOL-catalyzed alkynylation of alpha-ketoimine ester: a new entry to optically active quaternary alpha-CF3 alpha-amino acids
Gaochao Huang et al.
CHEMICAL COMMUNICATIONS (2011)
Cobalt-catalyzed conjugate addition of silylacetylenes to alpha,beta-unsaturated ketones
Takahiro Nishimura et al.
CHEMICAL COMMUNICATIONS (2011)
Highly enantioselective yttrium(III)-catalyzed Friedel-Crafts alkylation of beta-trichloro(trifluoro)methyl aryl enones with indoles
Wentao Wang et al.
CHEMICAL COMMUNICATIONS (2011)
Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates
Jing Nie et al.
CHEMICAL REVIEWS (2011)
Cooperative Activation of Alkyne and Thioamide Functionalities; Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides
Ryo Yazaki et al.
CHEMISTRY-AN ASIAN JOURNAL (2011)
Virtual screening studies on HIV-1 reverse transcriptase inhibitors to design potent leads
S. Vadivelan et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
A New Synthetic Approach to Efavirenz through Enantioselective Trifluoromethylation by Using the Ruppert-Prakash Reagent
Hiroyuki Kawai et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center
Lele Wen et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Enantioselective Synthesis of a GPR40 Agonist AMG 837 via Catalytic Asymmetric Conjugate Addition of Terminal Alkyne to α,β-Unsaturated Thioamide
Ryo Yazaki et al.
ORGANIC LETTERS (2011)
Fluorine & chirality: how to create a nonracemic stereogenic carbon-fluorine centre?
Dominique Cahard et al.
CHEMICAL SOCIETY REVIEWS (2010)
Synthesis of Functionalized Indoles with a Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Atom Through an Enantioselective Friedel-Crafts Alkylation with beta-Trifluoromethyl-alpha,beta-enones
Gonzalo Blay et al.
CHEMISTRY-A EUROPEAN JOURNAL (2010)
Practical Asymmetric Conjugate Alkynylation of Meldrum's Acid-Derived Acceptors: Access to Chiral β-Alkynyl Acids
Sheng Cui et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Direct Catalytic Asymmetric Conjugate Addition of Terminal Alkynes to α,β-Unsaturated Thioamides
Ryo Yazaki et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane
Hiroyuki Kawai et al.
ORGANIC LETTERS (2010)
Ni(II)-Catalyzed Enantioselective Conjugate Addition of Acetylenes to α,β-Enones
Oleg V. Larionov et al.
ORGANIC LETTERS (2010)
Asymmetric syntheses of a GPR40 receptor agonist via diastereoselective and enantioselective conjugate alkynylation
Jacqueline C. S. Woo et al.
TETRAHEDRON (2010)
Highly diastereoselective synthesis of α-trifluoromethylated α-propargylamines by acetylide addition to chiral CF3-substituted N-tert-butanesulfinyl ketimines
Hengqiao Xiao et al.
TETRAHEDRON-ASYMMETRY (2010)
Asymmetric Synthesis of beta-Alkynyl Aldehydes by Rhodium-Catalyzed Conjugate Alkynylation
Takahiro Nishimura et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Design, Synthesis, and Biological Evaluation of (2R,αS)-3,4-Dihydro-2-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-5-[3-(trifluoromethoxy)-phenyl]-α-(trifluoromethyl)-1(2H)-quinolineethanol as Potent and Orally Active Cholesteryl Ester Transfer Protein Inhibitor
Gee-Hong Kuo et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Enantioselective Rhodium-Catalyzed Conjugate Alkynylation of 5-Benzylidene Meldrum's Acids with TMS-acetylene
Eric Fillion et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Enantioselective Zirconium-Catalyzed Friedel-Crafts Alkylation of Pyrrole with Trifluoromethyl Ketones
Gonzalo Blay et al.
ORGANIC LETTERS (2009)
α-Trifluoromethylated carbanion synthons
Kenji Uneyama et al.
ACCOUNTS OF CHEMICAL RESEARCH (2008)
Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
Jun-An Ma et al.
CHEMICAL REVIEWS (2008)
Fluorine in medicinal chemistry
Sophie Purser et al.
CHEMICAL SOCIETY REVIEWS (2008)
Steric tuning of silylacetylenes and chiral phosphine ligands for rhodium-catalyzed asymmetric conjugate alkynylation of enones
Takahiro Nishimura et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
Fluorination in medicinal chemistry: Methods, strategies, and recent developments
Kenneth L. Kirk
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2008)
Fluorinated organophosphates for biomedical targets
Vadim D. Romanenko et al.
TETRAHEDRON (2008)
TTMPP-catalyzed trifluoromethylation of carbonyl compounds and imines with trifluoromethylsilane
Satoru Matsukawa et al.
TETRAHEDRON LETTERS (2008)
A first high enantiocontrol of an asymmetric tertiary carbon center attached with a fluoroalkyl group via Rh(I)-catalyzed conjugate addition reaction
Tsutornu Konno et al.
TETRAHEDRON LETTERS (2008)
Recent advances in enantioselective trifluoromethylation reactions
Norio Shibata et al.
TETRAHEDRON-ASYMMETRY (2008)
Nonsteroidal glucocorticoid agonists: Tetrahydronaphthalenes with alternative steroidal a-ring mimetics possessing dissociated (transrepression/transactivation) efficacy selectivity
Keith Biggadike et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
Direct, catalytic enantioselective nitroaldol (Henry) reaction of trifluoromethyl ketones:: An asymmetric entry to α-trifluoromethyl-substituted quaternary carbons
Fernando Tur et al.
ORGANIC LETTERS (2007)
Process research and development of an NK-1 receptor antagonist. enantioselective trifluoromethyl addition to a ketone in the preparation of a chiral isochroman
Stephane Caron et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2007)
Fluorine in pharmaceuticals:: Looking beyond intuition
Klaus Mueller et al.
SCIENCE (2007)
Cinchona Alkaloids/TMAF combination-catalyzed nucleophilic enantioselective trifluoromethylation of aryl ketones
Satoshi Mizuta et al.
ORGANIC LETTERS (2007)
How to reach stereogenic trifluoromethylated carbon? En route to the grail of the asymmetric trifluoromethylation reaction
Thierry Billard et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2007)
Synthesis and SAR of [1,2,4]Triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition
Nan Zhang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
The role of fluorine in medicinal chemistry
Poonam Shah et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2007)
An efficient method for the preparation of chiral Mosher's acid analogues
Y Kawano et al.
CHEMISTRY LETTERS (2006)
Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K
WC Black et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Catalytic, enantioselective, conjugate alkyne addition
TF Knöpfel et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Synthesis of enantiomerically pure α-ethyl, α-vinyl and α-ethynyl 3,3,3-trifluoro alaninates
M Crucianelli et al.
JOURNAL OF FLUORINE CHEMISTRY (2004)
Synthesis and evaluation of stereopure α-trifluoromethyl-malic hydroxamates as inhibitors of matrix metalloproteinases
M Sani et al.
TETRAHEDRON LETTERS (2004)
Catalytic enantioselective conjugate addition of trimethylsilylacetylene to 2-cyclohexen-1-one
YS Kwak et al.
ORGANIC LETTERS (2004)
Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions
JA Ma et al.
CHEMICAL REVIEWS (2004)
Highly enantioselective construction of a chiral tertiary carbon center by alkynylation of a cyclic N-acyl ketimine: An efficient preparation of HIV therapeutics
B Jiang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2004)
Activity predictions for efavirenz analogues with the K103N mutant of HIV reverse transcriptase
M Udier-Blagovic et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2003)
Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors
M Patel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase
JW Corbett et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2001)
An efficient chiral moderator prepared from inexpensive (+)3-carene: Synthesis of the HIV-1 non-nucleoside reverse transcriptase inhibitor DPC 963
GS Kauffman et al.
ORGANIC LETTERS (2000)
Asymmetric conjugate addition of alkynylboronates to enones
JM Chong et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)