Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 49, Pages 6454-6457Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01210k
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Funding
- National Program on Key Basic Research Project of China (973 Program) [2012CB720603]
- National Science Foundation of China [21232005, 51133004, J1310008, J1103315]
- State Key Lab of Oral Diseases (Sichuan University) [SKLODOF2014OF01]
- Specialized Research Fund for the Doctoral Program of Higher Education in China [20120181130006]
- Program for New Century Excellent Talents in University [NCET-11-0354]
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Cationic oligomers with a rigid aromatic backbone were first applied as non-viral gene delivery vectors. These materials showed better DNA condensation ability than their flexible analogues. In vitro transfection experiments revealed that the materials with more rigid backbone exhibited considerably higher TE and lower cytotoxicity than 25 kDa PEI.
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