4.7 Article

A boronate-based fluorescent probe for the selective detection of cellular peroxynitrite

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 66, Pages 9353-9356

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02943g

Keywords

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Funding

  1. National Research Foundation grant - Korean government [NRF-2013M2B2A4041354, NRF-2012121A1A2038694]
  2. National Research Foundation of Korea [2012R1A1A2038694, 2013M2B2A4041354] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A boronate-based fluorescent probe 1 for the selective monitoring of intracellular peroxynitrite has been developed. The probe takes advantage of the fast reaction of an arylboronate group with peroxynitrite, yielding a corresponding phenol that undergoes spontaneous subsequent reactions to produce a strongly fluorescent product associated with a large turn-on signal.

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