Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 3, Pages 368-370Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc46973e
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Funding
- National Research Foundation of Korea
- NIH-NIGMS
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN272200700057C, HHSN272201-200025C]
- NIH
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI070090] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM110569] Funding Source: NIH RePORTER
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Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.
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