4.7 Article

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 41, Pages 5487-5489

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01924e

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Funding

  1. DFG (SFB TR51 ``Roseobacter'')
  2. Fonds der Chemischen Industrie with a Chemiefonds Scholarship

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The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

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