Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 91, Pages 14253-14256Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc07561g
Keywords
-
Categories
Funding
- NSFC [21405172, 21275158]
- Innovation Projects of the CAS [KZCX2-EW-206]
- program of Youth Innovation Promotion Association, CAS
Ask authors/readers for more resources
We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available