4.7 Article

A molecular rotor for measuring viscosity in plasma membranes of live cells

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 40, Pages 5282-5284

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47530a

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Funding

  1. EPSRC for Career Acceleration Fellowships
  2. European Commission in the form of Marie Curie individual Fellowships
  3. EPSRC [EP/J001538/1] Funding Source: UKRI
  4. Engineering and Physical Sciences Research Council [EP/J001538/1] Funding Source: researchfish

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Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane.

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