Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 2, Pages 216-218Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47382a
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Funding
- U.S. NIH [R01GM097468]
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We report a new class of deubiquitinating enzyme (DUB) probes that resemble the native diubiquitin with a same linkage size and contain a Michael addition acceptor for trapping the DUB active-site cysteine. Both K63- and K48-linked diubiquitin probes were generated using a facile chemical ligation method. The diUb probes were demonstrated to label DUBs from different families and revealed intrinsic linkage specificities of DUBs.
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