Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 79, Pages 11672-11675Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04915b
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Funding
- CRI project [2009-0081566]
- National Research Foundation of Korea - Ministry of Science, ICT and Future Planning [2012R1A1A2006259]
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We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, epsilon) enhanced from 18.5 to 21.1.
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