4.7 Article

A near-infrared-emitting fluorescent probe for monitoring mitochondrial pH

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 54, Pages 7184-7187

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01390e

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Funding

  1. 973 Program [2013CB933800]
  2. National Natural Science Foundation of China [21227005, 21390411, 91313302, 21035003a, 21205073]
  3. Program for Changjiang Scholars and Innovative Research Team in University

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We demonstrate a new small molecule fluorescent probe, possessing near-infrared (NIR) emission and an unusually large Stokes shift. It can be readily taken up by live cells and mitochondria, and track subtle pH changes with effectively reduced biological background fluorescence and improved measurement accuracy.

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