4.7 Article

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 32, Pages 4161-4163

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48934e

Keywords

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Funding

  1. The Research Grant Council of the Hong Kong Special Administrative Region Government [9041748, 9041948]
  2. Centre for Biosystems, Neuroscience, and Nanotechnology at City University of Hong Kong
  3. City University of Hong Kong Startup Fund [7200263, 7003028]
  4. Hong Kong Research Grants Council [HKBU202410, HKUST2/CRF/10]
  5. National Basic Research Program of China (973 Program) [2013CB834702]

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Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L-1)](2)(mu-dppm)}(2+) (1) and {[Pt(L-2)](2)(mu-dppm)}(2+) (2), as lysosome-specific two-photon imaging probes.

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