Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 30, Pages 3947-3950Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00561a
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Funding
- Direction Generale de l'Armement through BIOMEDEF action [PDH-2-NRBC-4-C-403]
- Agence Nationale pour la Recherche [ANR_06_BLAN_0163, ANR_09_BLAN_0192]
- DTRA [HDTRA1-11-C-0047]
- Region Haute Normandie (Crunch program)
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Two promising uncharged reactivators for inhibited human BChE and AChE have been described. These compounds show an ability to reactivate VX-inhibited BChE largely superior to those of known pyridinium aldoximes. Moreover, these oximes also exhibit a good ability to reactivate VX-, tabun- and paraoxon-inhibited human AChE.
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