4.7 Article

Palladium(0)-catalyzed cyclopropanation of benzyl bromides via C(sp3)-H bond activation

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 28, Pages 3692-3694

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49231a

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Funding

  1. Natural Science Foundation of China [21072168]

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A novel and highly efficient Pd(0)-catalyzed domino reaction to prepare cyclopropane derivatives has been established. The process involves a Heck-type coupling reaction and a C(sp(3))-H bond activation. Preliminary DFT calculations suggest that a four-membered palladacycle intermediate is involved.

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