Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 43, Pages 5741-5744Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02011a
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Funding
- CRI project [2009-0081566]
- Basic Science Research Program [2012R1A1A2006259]
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2011-0014188]
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We herein report a fluorescence probe 1 capable of detecting water-soluble oligomeric Ab aggregates and A beta fibrils. Upon injection into A beta(42)-challenged mouse brains, probe 1 shows increased fluorescence intensity, indicating its facile binding to extracellular Ab fibrils in brain tissues.
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