Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 98, Pages 15533-15536Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc07888h
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Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I001824/1, BB/I001182/1]
- MRC programme [U117512723]
- BBSRC [BB/L018853/1, BB/I001182/1, BB/L004240/1, BBS/E/I/00001422, BB/I001824/1] Funding Source: UKRI
- EPSRC [EP/K039946/1] Funding Source: UKRI
- MRC [MC_U117512723] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/I001182/1, BB/L018853/1, BB/I001824/1, BBS/E/I/00001025, BBS/E/I/00001422, BB/L004240/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/K039946/1] Funding Source: researchfish
- Medical Research Council [MC_U117512723] Funding Source: researchfish
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RNA aptamers showing affinity and specificity for different strains of human influenza virus were assembled onto gold nanoparticles that subsequently formed a gold nanoshell (AuNS) around the viral envelope. These shells could be visualised by transmission electron microscopy (TEM). Changes in size and structure of the AuNS coated virus can be used to detect the viruses. We show that sedimentation with a low cost centrifuge and visual determination can detect 3 x 10(8) viral particles.
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