4.7 Article

A novel graphene oxide based fluorescent nanosensing strategy with hybridization chain reaction signal amplification for highly sensitive biothiol detection

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 80, Pages 11879-11882

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05309e

Keywords

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Funding

  1. National Natural Science Foundation of China [21275045, 21205034]
  2. Doctoral Fund of Ministry of Education of China (New Teachers) [20120161120032]
  3. Hunan Provincial Natural Science Foundation of China [12JJ1004, 13JJ4031]
  4. [NCET-11-0121]

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A novel fluorescent nanosensor has been developed for detecting biothiols including cysteine and glutathione using graphene oxide based hairpin DNA-selective fluorescence quenching and thymine-Hg(II)-thymine coordination-controlled hybridization chain reaction, which provides a simple but the most sensitive platform for biothiol assays.

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