4.7 Article

Solid phase microextraction (SPME)-transmission mode (TM) pushes down detection limits in direct analysis in real time (DART)

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 85, Pages 12937-12940

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc05301j

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Funding

  1. Natural Sciences and Engineering Research Council (NSERC) of Canada
  2. Supelco
  3. IonSense Inc.
  4. VBM Science Ltd.

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A new SPME device was developed and applied for quick solventless extraction/enrichment of small molecules from complex matrices. Subsequently, the device was coupled as a transmission mode substrate to DART resulting in limits of detection in the low pg mL(-1) level in less than 3 minutes with reproducibility below 5% RSD.

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