Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 92, Pages 14451-14454Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc07128j
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Funding
- National Basic Research Program of China (973 Program) [2013CB834701]
- Research Grants Council of Hong Kong [604913, 604711, 6602212, 16301614, N_HKUST620/11]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- Guangdong Innovative Research Team Program [201101C0105067115]
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We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.
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