4.7 Article

Design, synthesis and biological evaluation of mitochondria targeting theranostic agents

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 64, Pages 8919-8922

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03296a

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Funding

  1. Office of Science (BER), U.S. Department of Energy [DE-SC0008397]
  2. NIH In vivo Cellular Molecular Imaging Center (ICMIC) [P50 CA114747]

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Dual mitochondria targeting fluorescent F16-TPP analogues were designed and synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16-TPP, two compounds discovered in this study, are promising mitochondria targeting theranostic agents.

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