Chemoselective reduction of α-keto amides using nickel catalysts

Ni-catalysts are used for the first time to synthesize highly important alpha-hydroxy amides and beta-amino alcohols from alpha-keto amides by chemoselective and complete reduction using hydrosilanes. Chemo-selective complete reduction of alpha-keto amides in the presence of a simple amide group is a key benefit of these Ni-catalysts.