4.7 Article

Metal-free nitro-carbocyclization of activated alkenes: a direct approach to synthesize oxindoles by cascade C-N and C-C bond formation

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 5, Pages 554-556

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47336h

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Funding

  1. National Science Foundation of China [21172006]
  2. Ministry of Education of China [20120001110013]

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A novel and direct metal-free nitro-carbocyclization of activated alkenes leading to valuable nitro-containing oxindoles via cascade C-N and C-C bond formation has been developed. The mechanistic study indicates that the initial NO and NO2 radical addition and the following C-H functionalization processes are involved in this transformation.

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