4.7 Article

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 40, Pages 5336-5338

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47427e

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Funding

  1. European Research Council under the European Community's Seventh Framework Programme [249835]
  2. PhD training program in France of the University of Science and Technology of Hanoi
  3. CNRS

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Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.

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