Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 53, Pages 6987-6990Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02119c
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Funding
- Natural Science Foundation of China [30973619, 81172931]
- National High-tech RD 863 Program [2008AA02Z304]
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A simple and novel furanyl acryl conjugated coumarin fluorophore was designed as an effective thioredoxin reductase (TrxR)-responding fluorescent probe by an activity-guided approach. Basically, the alpha,beta-unsaturated ketone moiety in the probe structure could quench the fluorescence of the coumarin, but upon the covalent modification of TrxR, a significant fluorescence could be generated, which has been confirmed to be obviously selective over Trx, GSH, Cys and DTT.
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