4.7 Article

nBu(4)NI-Catalyzed oxidative imidation of ketones with imides: synthesis of alpha-amino ketones

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 18, Pages 2367-2369

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48887j

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Funding

  1. SRFDP [20110043110002]
  2. NNSFC [21372041, 21302017]
  3. Fundamental Research Funds for the Central Universities [11GJHZ001, 11QNJJ015]

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nBu(4)NI-Catalyzed oxidative imidation of ketones and imides for the synthesis of a-amino ketones were realized for the first time. The methodology is characterized by its wide substrate scope even for acetone with readily available phthalimide, saccharin and succinimide, which opens a new pathway for direct imidation of ketones.

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