4.7 Article

A novel nanogel-based fluorescent probe for ratiometric detection of intracellular pH values

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 63, Pages 8787-8790

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03716b

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Funding

  1. National Basic Research Program [2013CB834505, 2013CB834703, 2011CBA00905, 2009CB930802]
  2. National Natural Science Foundation of China [21073206, 21072196, 21233011, 21205122]

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A new nanogel indicator (NGI) for ratiometric fluorescent detection of intracellular pH values has been reported. In aqueous solution, the NGI can be used for ratiometric sensing of pH changes with a large hypsochromic shift of 100 nm in the green-red region and reversible. Furthermore, the NGI has been used to calibrate the cytosol pH value in living cells.

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