4.7 Article

Modular automated solid phase synthesis of dermatan sulfate oligosaccharides

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 15, Pages 1875-1877

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48860h

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Funding

  1. Max-Planck Society
  2. European Research Council (ERC Advanced Grant AUTOHEPARIN)

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Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo-cleavable linker are instrumental for the automated synthesis of dermatan sulfate oligosaccharides. Conjugation-ready oligosaccharides were obtained in good yield.

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