Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 14, Pages 1688-1690Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48650h
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Funding
- ARC Centre of Excellence for Free Radical Chemistry and Biotechnology
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Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
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