4.7 Article

Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 42, Pages 5547-5550

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00620h

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Funding

  1. Australian Research Council
  2. National Health and Medical Research Council Early Career Fellowship
  3. Australian National Fabrication Facility
  4. Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
  5. University of Queensland

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Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.

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