4.7 Article

Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 56, Pages 7440-7443

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02703e

Keywords

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Funding

  1. Spanish Ministerio de Economia y Competitividad [SAF2010-15670, CTQ2010-15848]
  2. Junta de Andalucia
  3. COST action MULTIGLYCONANO [CM1102]
  4. European Regional Development Funds (FEDER and FSE)
  5. Italian Ministry of Instruction, University and Research (MIUR)

Ask authors/readers for more resources

Stable core-shell nanospheres self-assemble in water from heterodimers combining a hydrophobic calix[4]arene moiety and a hydrophilic beta-cyclodextrin head; their potential to encapsulate and provide sustained release of the anticancer drug docetaxel and undergo surface post-modification with glycoligands targeting the macrophage mannose receptor is discussed.

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