Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 46, Pages 6098-6100Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49080g
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Funding
- German academic exchange service (DAAD)
- Austrian BMWFJ
- BMVIT
- SFG
- Standortagentur Tirol
- ZIT through the Austrian FFG-COMET-Funding Program
- EPSRC [EP/G005834/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/G005834/1] Funding Source: researchfish
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An efficient and sustainable biocatalytic route for the synthesis of important 17-alpha-amino steroids has been developed using an omega-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.
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