4.7 Article

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 58, Pages 7806-7809

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01061b

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Funding

  1. National Natural Science Foundation of China [21202147]
  2. Chinese High Tech Research & Development (863) Program [2012AA020204, SS2014AA020534]
  3. National ST Major Project [2012ZX10002017]
  4. Natural Science Foundation of Zhejiang Province [LY13H090013]

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Chimeric peptides composed of arginine-rich RNA-binding and tumor cell-targeting motifs have been employed to condense siRNA to form supramolecular nanoparticles via electrostatic associations and deliver siRNA agents in a tumor cell-specific manner.

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