4.7 Article

One-pot synthesis of β-N-glycosyl imidazole analogues via a palladium-catalysed decarboxylative allylation

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 32, Pages 4222-4224

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48041k

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Funding

  1. Nanyang Technological University [RG50/08]
  2. NMRC from Ministry of Health, Singapore [H1N1R/001/2009]

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A concise and highly efficient strategy for the synthesis of N-glycosyl imidazole analogues is reported. This reaction is based on a palladium catalysed decarboxylative allylation and three steps, namely, carbamation, decarboxylation and allylation are involved. All the substrates can afford the desired products with excellent yields and selectivities.

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