4.7 Article

Manganese porphyrin-double stranded DNA complex guided in situ deposition of polyaniline for electrochemical thrombin detection

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 54, Pages 7169-7172

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02608j

Keywords

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Funding

  1. NNSF of China [21075100, 21275119, 21105081]
  2. Ministry of Education of China [708073]
  3. Natural Science Foundation of Chongqing City [CSTC-2011BA7003, CSTC-2010BB4121]
  4. Fundamental Research Funds for the Central Universities [XDJK2013A008, XDJK2014C138C]

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In this work, we proposed a novel electrochemical strategy for sensitive detection of thrombin (TB) based on in situ generation of polyaniline (PANI) as a redox mediator by using a manganese porphyrin-double stranded DNA (MnTMPyP-dsDNA) peroxidase-like artificial enzyme mimic as a powerful catalyst and template.

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