Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 89, Pages 13789-13792Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06577h
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Funding
- Caltech-City of Hope Biomedical Research Initiative
- Caltech Summer Undergraduate Research Fellowship program
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We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
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