Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 38, Pages 4895-4897Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc01643b
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- National Science Foundation [CH 1213415]
- Defense Threat Reduction Agency Joint Science and Technology Office
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A cavitand with ionic, but nonionizable feet folds around hydrophobic guests in D2O. Short alkanes and ibuprofen are included and exchange rates are slow on the NMR timescale. Normal octanoyl groups show good affinity for the cavitand and the gastric peptide ghrelin is bound at low pH and physiological temperature.
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