4.7 Article

Supramolecular polymeric peptide amphiphile vesicles for the encapsulation of basic fibroblast growth factor

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 23, Pages 3033-3035

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49074b

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Funding

  1. A STAR for a Postdoctoral Fellowship
  2. Marie Curie Intraeuropean Fellowship
  3. ERC Starting Investigator Grant [ASPiRe 240629]
  4. Walters-Kundert Foundation
  5. EPSRC [EP/F035535/1] Funding Source: UKRI
  6. Engineering and Physical Sciences Research Council [EP/F035535/1] Funding Source: researchfish

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The synthesis of a supramolecular double hydrophilic peptide-conjugated polymer held together by cucurbit[8] uril (CB[8]) ternary complexation and its subsequent temperature triggered self-assembly into vesicles are described. Basic fibroblast growth factor can be easily loaded into the vesicles under benign conditions and their bioactivities can be preserved without the need for excipients such as heparin.

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