4.7 Article

Spermidinium closo-dodecaborate-encapsulating liposomes as efficient boron delivery vehicles for neutron capture therapy

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 82, Pages 12325-12328

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04344h

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Funding

  1. Ministry of Health, Labor and Welfare [20100201]
  2. Ministry of Education, Science, Sports, Culture and Technology, from Japan [23390018]
  3. Grants-in-Aid for Scientific Research [23390018, 26293007] Funding Source: KAKEN

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closo-Dodecaborate-encapsulating liposomes were developed as boron delivery vehicles for neutron capture therapy. The use of spermidinium as a counter cation of closo-dodecaborates was essential not only for the preparation of high boron content liposome solutions but also for efficient boron delivery to tumors.

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