4.7 Article

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 25, Pages 3350-3352

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48190e

Keywords

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Funding

  1. Centre National de la Recherche Scientifiques (CNRS)
  2. Science Foundation Ireland (SFI)
  3. Principal Investigator Award [07/IN1/B1792]
  4. IUPAC glycopeptides project [AC-POL-09-11-25]
  5. ESF Precision PolymerMaterials'' program
  6. Spanish Ministerio de Economia y Competitividad [SAF2010-15670]
  7. Fondo Europeo de Desarrollo Regional (FEDER)
  8. Fondo Social Europeo (FSE)
  9. Fundacion Ramon Areces
  10. Institut Universitaire de France (IUF)
  11. Agence Nationale de la Recherche (ANR) [11-BS07-003-02]
  12. CNRS [UMR 7509, FRE 3511]
  13. University of Strasbourg
  14. University of Poitiers
  15. Agence National de la Recherche (ANR) [11-BS07-003-02, 08JC-0094-01]

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Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkablemultivalency properties when inhibiting alpha-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.

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