4.7 Article

Two Pb2+-specific DNAzymes with opposite trends in split-site-dependent activity

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 34, Pages 4442-4444

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00864b

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Funding

  1. University of Waterloo
  2. Canadian Foundation for Innovation
  3. Natural Sciences and Engineering Research Council (NSERC) of Canada
  4. Early Researcher Award from the Ministry of Research and Innovation of Ontario

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By splitting the catalytic core of DNAzymes into two halves, two Pb2+-specific DNAzymes retain partial activity, while they show opposite trends of activity as a function of the split site, revealing important nucleotides for catalysis and metal binding.

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