Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 78, Pages 11480-11483Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04182h
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Funding
- National Natural Science Foundation of China [2129018, 21321061, 21172151]
- National Basic Research Program of China (973 Program) [2010CB808600]
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An efficient enantioselective [3+2] cycloaddition of alkynes with oxiranes via selective C-C bond cleavage of epoxides was developed. A number of optically active 2,5-dihydrofurans were obtained in excellent yields (up to 99%) and enantioselectivities (up to 95% ee) under mild reaction conditions. Moreover, chiral tetrahydrofuran could also be obtained by cycloaddition of alkene and oxirane or hydrogenation of chiral 2,5-dihydrofuran.
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