Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 64, Pages 8934-8936Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03896g
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Funding
- NSFC [21032005, 21172097, 21372105]
- National Basic Research Program of China [2010CB833203]
- International S&T Cooperation Program of China [2013DFR70580]
- National Natural Science Foundation from Gansu Province of China [1204WCGA015]
- 111 program from MOE of P. R. China
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A catalytic asymmetric hetero-Diels-Alder (HDA) reaction has been achieved through hydrogen-bond directed gamma-addition of olefinic azlactones to isatins. This methodology provides an efficient access to spirooxindole dihydropyranones in moderate to good yields and with excellent enantioselectivities.
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