4.7 Article

Ultrafast colorimetric detection of nucleic acids based on the inhibition of the oxidase activity of cerium oxide nanoparticles

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 67, Pages 9577-9580

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03841j

Keywords

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Funding

  1. Center for BioNano Health-Guard - Ministry of Science, ICT and Future Planning (MSIP) of Korea as Global Frontier Project [H-GUARD-2013M3A6B2078964]
  2. Public Welfare & Safety Research Program through the National Research Foundation of Korea (NRF) - MSIP [2012M3A2A1051683]
  3. Industrial Source Technology Development Program of the Ministry of Trade, Industry Energy (MOTIE) [2010-10038662]

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A label-free colorimetric method to detect nucleic acids, which relies on target DNA induced shielding of the oxidase activity of CeO2 NPs, is developed. With this novel strategy, target nucleic acids can be identified within a few minutes and without the need for post-purification of PCR products.

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