4.7 Article

Polyacrylic acid@zeolitic imidazolate framework-8 nanoparticles with ultrahigh drug loading capability for pH-sensitive drug release

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 8, Pages 1000-1002

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc47666a

Keywords

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Funding

  1. National Natural Science Foundation of China [21173038, 21301027]
  2. Natural Science Foundation and Science and Technology Development Planning of Jilin Province [201215003, 201201115, 20130522136JH]
  3. Science Foundation for Young Teachers of Changchun University of Science and Technology [XQNJJ-2011-11]
  4. Program for New Century Excellent Talents in University [NCET-13-0720]
  5. Fundamental Research Funds for the Central Universities [12SSXM005]

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The polyacrylic acid@zeolitic imidazolate framework-8 (PAA@ZIF-8) nanoparticles (NPs) were first fabricated using a facile and simple route. It is worthwhile noting that the as-fabricated PAA@ZIF-8 NPs possessed ultrahigh doxorubicin (DOX) loading capability (1.9 g DOX g(-1) NPs), which were employed as pH-dependent drug delivery vehicles.

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