4.7 Article

Linker-determined drug release mechanism of free camptothecin from self-assembling drug amphiphiles

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 45, Pages 6039-6042

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc49453e

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Funding

  1. National Science Foundation [DMR 1255281]
  2. NIH [T-32CA130840]
  3. Direct For Mathematical & Physical Scien
  4. Division Of Materials Research [1255281] Funding Source: National Science Foundation

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We report here that the release mechanism of free camptothecin from self-assembling drug amphiphiles can be regulated by use of different linker groups. Our results highlight the significance of the linker group of drug amphiphiles on the drug release efficiency and their consequent in vitro efficacy.

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