Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 99, Pages 15780-15783Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06653g
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Funding
- National Natural Science Foundation of China [51273156, 31301735]
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A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.
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