Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 93, Pages 14498-14500Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc04280h
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Funding
- Danish Council for Independent Research, Technology and Production Sciences, Denmark
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The release of azidothymidine from macromolecular prodrugs was designed to respond to the intracellular disulfide reshuffling. This drug has no thiol groups, and a response to this trigger was engineered using a self-immolative linker. The resulting formulations were fast-acting, efficacious, and highly potent with regards to suppressing the infectivity of the virus.
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