4.7 Article

Semi-artificial and bioactive ferroxidase with nanoparticles as the active sites

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 59, Pages 8021-8023

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03477e

Keywords

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Funding

  1. Marie Curie Actions (CIG) [322158]
  2. Spanish Ministry of Economy and Competitivity (MINECO) [MAT2012-38161]
  3. Basque government [PI2013-56]

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Light-chain apoferritin lacks ferroxidase activity, which can be supplemented with Pt-nanoparticles. The hybrid bioinorganic nanoparticle outperforms its heavy-chain pendant in terms of ferroxidase activity, mineralization ability and inhibition resistance. Being active in a cellular environment it regulates the iron homeostasis.

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